Author(s) :
Raquel Sánchez1, Raquel Ciérvide1, Beatriz Alvarez1, Mercedes Lopez1, Bruno Esteban1, Daniel Zuca2, Carmen Rubio1
1 Radiation Oncology Department, University Hospital HM Sanchinarro, Madrid, Spain
2 Medical Physics Department, University Hospital HM Sanchinarro, Madrid, Spain
Corresponding author: Raquel Sanchez, Email: raquelsc53@gmail.com
Publication History: Received - 20 November 2025, Revised - 3 August 2026, Accepted - 30 August 2026, Published Online - 30 September 2026.
Copyright: © 2026 The author(s). Published by Casa Cărții de Știință.
User License: Creative Commons Attribution – NonCommercial (CC BY-NC)
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Abstract
Primary cardiac sarcomas are extremely rare and aggressive cancers with a generally poor prognosis and limited treatment options. Surgery remains the mainstay of management, but local recurrence is frequent even after apparently complete resection.
We describe the case of a 56-year-old woman with a recurrent dedifferentiated liposarcoma of the left atrium following mitral valve replacement. The recurrence was treated with stereotactic body radiotherapy (SABR) delivered by volumetric modulated arc therapy (VMAT) under deep inspiration breath-hold (DIBH). A total dose of 32.5 Gy in five fractions was administered. The treatment was well tolerated, with no acute cardiac or pulmonary toxicity and preserved valve function. Two months after treatment, lesion remains stable and no altered cardiac function. This case supports the feasibility and safety of SABR-VMAT with DIBH for recurrent cardiac sarcoma, offering an effective local option when surgery or MR-guided RT are not available.