Author(s) :
Răzvan Lăpădat1
1 Department of Pathology, Loyola University Medical Center, Maywood, IL, USA;
Corresponding author: Răzvan Lăpădat, Email: rlapadat@gmail.com
Publication History: Received - , Revised - , Accepted - , Published Online - .
Copyright: © The author(s). Published by Casa Cărții de Știință.
User License: Creative Commons Attribution – NonCommercial (CC BY-NC)
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Abstract
Pineoblastomas are rare, malignant pineal parenchymal tumors encountered predominantly in pediatric patients. They are distinct from primitive neuroectodermal tumors (PNET) at other sites in that they exhibit photosensory differentiation including Flexner–Wintersteiner rosettes and fleurettes. Diagnosis can be challenging since they share morphologic and immunohistochemical features with other embryonal tumors and the developing pineal gland. Pineal anlage is a rare variant of pineoblastoma defined by divergent neuroepithelial and ectomesenchymal differentiation without an endodermal component. To date the five published cases of anlage tumors behaved aggressively. We describe a case series which includes one patient with pineal anlage tumor and the clinical, radiological and pathological characteristics of pediatric pineoblastomas.