Pineoblastomas in Pediatric Patients: The Children’s Hospital of Wisconsin Experience

Author(s) :

Răzvan Lăpădat1

1 Department of Pathology, Loyola University Medical Center, Maywood, IL, USA;


Corresponding author: Răzvan Lăpădat, Email:

Published: Volume II, Issue 1, July 2022, 39-47, , , - DOI:

Open Access

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July 1, 2022 0 Comments


Pineoblastomas are rare, malignant pineal parenchymal tumors encountered predominantly in pediatric patients. They are distinct from primitive neuroectodermal tumors (PNET) at other sites in that they exhibit photosensory differentiation including Flexner–Wintersteiner rosettes and fleurettes. Diagnosis can be challenging since they share morphologic and immunohistochemical features with other embryonal tumors and the developing pineal gland. Pineal anlage is a rare variant of pineoblastoma defined by divergent neuroepithelial and ectomesenchymal differentiation without an endodermal component. To date the five published cases of anlage tumors behaved aggressively. We describe a case series which includes one patient with pineal anlage tumor and the clinical, radiological and pathological characteristics of pediatric pineoblastomas.

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