Author(s) :
Andrada Turcas123, Cristina Gheara14, Vlad Galatan1, Cristina Blag5, Dana Cernea 1
1Radiotherapy Department, Oncology Institute “Prof. Dr. Ion Chiricuta”, Cluj-Napoca, Romania
2Oncology Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania
3The European Society for Paediatric Oncology (SIOP Europe), Brussels, Belgium
4Faculty of Physics, Babeș-Bolyai University, Cluj-Napoca, Romania
5Clinical Emergency Hospital for Children – Pediatrics Clinic 2, Cluj-Napoca, Romania
Corresponding author: Andrada Turcas, Email: andradaturcas@outlook.com
Publication History: Received - , Revised - , Accepted - , Published Online - .
Copyright: © The author(s). Published by Casa Cărții de Știință.
User License: Creative Commons Attribution – NonCommercial (CC BY-NC)
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Valoarea DOI extrasă din ACF este: 10.53011/JMRO.2022.02.07
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Abstract
Nephroblastoma (Wilms tumor) is the most common kidney malignancy in children and one of the most frequent abdominal tumors diagnosed in pediatric patients. We present the case of a 2-year-old boy diagnosed with intermediate-risk, regressive-type nephroblastoma of the left kidney in 2010. He was treated with neoadjuvant chemotherapy followed by surgery and chemotherapy following the International Society of Pediatric Oncology (SIOP) protocol. After 11 months a metastasis was discovered in the left lung and the patient was (re)classified as being high risk and treated with seven cycles of chemotherapy. After nine disease-free years, the routine follow-up chest CT scan showed a 10/5cm tumor in the left lung involving the pleura. The tumor was completely resected, and pathology confirmed a distal recurrence of nephroblastoma. The patient was further treated according to the UMBRELLA protocol (BB group) with chemotherapy and local irradiation. The tumor bed was irradiated with 25.2 Gy/14 fr, using Helical Tomotherapy. Following radiotherapy, he received a high dose chemotherapy and autollogus stem-cell transplant, with a good response and without disease recurrence.
