Author(s) :

Catalin Stefan, Mariana, Livia Marieta .

Volume/Issue :

Abstract :

Intraductal papillary neoplasms of the bile duct (IPNB) are rare precancerous lesions that play a role in the development of cholangiocarcinoma (CCA). They were finally recognised as a separate entity in the World Health Organisation's 2019 classification of tumours of the digestive system. Based on the new histological and clinical criteria of 2019, it is divided into types: 1 and 2. Neoplasms of the biliary tract usually develop through an evolutionary process that includes various preliminary stages, from the first lesion that can only be recognised microscopically (biliary intraepithelial neoplasia) through the various grades of IPNB to the final stage, invasive cholangiocarcinoma. New investigations, mainly based on magnetic resonance imaging (MRI), ERCP and cholangioscopy, are necessary to make a correct diagnosis and to correctly evaluate the biliary tract. Surgical resection is the mainstay of treatment, although endoscopic treatments are currently used in inoperable patients.

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