In Pursuit of Meaningfulness in the Biomedical Literature – Notes from a Scrap Booklet

Author(s) :

Monica-Emilia Chirilă1, Søren M. Bentzen2



1Clinical Development Department, MVision AI, Helsinki, Finland

2Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, USA

3Department of Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore


Corresponding author: Monica-Emilia Chirilă , Email:

Published: IiI, 2, 1 October 2023, 85 - 90 DOI: 10.53011/JMRO.2023.02.11

Open Access

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October 1, 2023 0 Comments


Professor Søren M. Bentzen is the Director of the Division of Biostatistics and Bioinformatics, Department of Epidemiology and Public Health, University of Maryland School of Medicine, USA, and he is also an Adjunct Professor of Radiobiology and Medical Physics, University of Copenhagen, Denmark.

Dr. Bentzen received a Master of Sciences in physics and mathematics, a PhD in medical image analysis, and he is a doctor of medical science in quantitative clinical radiobiology. He was one of the leaders of the Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC) initiative, and serves as a member of the Pediatric Normal Tissue Effects in the Clinic (PENTEC) steering committee. He was also a member of the American Society for Radiation Oncology (ASTRO) Task Forces to develop evidence-based guidelines on the appropriate fractionation for whole breast irradiation and for localized prostate cancer. He has served as chair or member of 17 (seven currently active) Independent Data and Safety Monitoring Committees or Trial Steering Committees and as co-chair for Translational Research for two Radiation Therapy Oncology Group (RTOG) phase III trials.

He has published more than 500 original papers and book chapters, has presented >370 invited lectures, and he currently serves on 10 international cancer journal editorial boards. His main research interests include bioeffect modeling; biomathematics; applied biostatistics; clinical trial design; evidence-based medicine; late effects of radiotherapy; clinical radiobiology; integration of data from genomics, proteomics, and molecular imaging into novel therapeutic strategies. He received more than 30 awards and honors by now, including the ASTRO Gold Medal and European Society for Radiation Oncology (ESTRO) Breuer Gold Medal (1).

This interview is meant to present in an interactive form some general elements that could help young clinicians to develop a critical approach when reading a medical research manuscript.

Please find here the whole interview.

Professor Søren M. Bentzen (photo source – personal archive)
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